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Report on the circumstances leading to the 1996 outbreak of infection with E.coli 0157 in Central Scotland, the implications for food safety and the lessons to be learned.
 
ANNEX IX
 
GLOSSARY
Asymptomatic Infection: An infection with a micro-organism where the person infected does not suffer any resulting symptoms or disease.
Bacterium: A microscopic organism with a rigid cell wall; often single celled and multiplies by splitting in two.
Case: A person in the population identified as having a particular disease.
Codex Alimentarius Commission: An international organisation, created by the World Health Organisation and the Food and Agriculture Organisation of the United Nations, which sets standards for food.
DH: Department of Health.
Epidemiology: The study of factors affecting health and disease in populations and the application of this study to the control and prevention of disease.
Haemolytic Uraemic Syndrome (HUS): A clinical condition which may arise from a variety of causes and which is characterised by anaemia and kidney failure.
Haemorrhagic Colitis (HC): Inflammation and bleeding from the large bowel that may be caused by infection.
Horizontal Regulations Regulations which apply to a wide range of premises (ie are not 'vertical' or product specific regulations).
Incidence: The proportion of the population that contracts a disease during a particular period of time.
Infectious Dose: The amount of infectious material (eg the number of bacteria) necessary to produce an infection.
MAFF: Ministry of Agriculture, Fisheries and Food.
Microflora: The microbial population of an area (eg such as the gastro-intestinal tract or the surface of meat).
Outbreak: Two or more cases of disease linked to a common source.
Prevalence: The proportion of a population having a specific disease at a given point in time.
Phage (Bacteriophage) Typing: A method for distinguishing varieties of bacteria (phage types) within a particular species.
SCIEH: Scottish Centre for Infection and Environmental Health.
Serology: The study of antigen-antibody reactions in vitro (ie in laboratory apparatus rather than a living organism).
SOAEFD: Scottish Office Agriculture, Environment and Fisheries Department.
SODoH: Scottish Office Department of Health.
Strain: A population of organisms within a species or sub-species distinguished by sub-typing.
Thrombotic Micro-Angiopathy (TMA): TMA describes the pathological process in the small blood vessels which results in HUS and TTP. It is defined by the following chemical and haematological surrogate markers plus any clinical evidence of established TTP or HUS:
 
a. evidence of red cell fragmentation on a blood film.
 
b. a lactate dehydrogenase level of greater than 1.5 times the upper limit of the laboratories' normal value.
 
c. a platelet count lower than 150 times 109
 
Thrombotic Thrombocytopaenia A clinical condition characterised by fever with skin
Purpura (TTP): and central nervous involvement, anaemia and kidney failure.
Toxin: Any poisonous substance produced by a micro-organism.
Typing: Any method used to distinguish between closely related micro-organisms.
Vertical Regulations: Product specific regulations which set out requirements for dealing with the product throughout the production process.
Virulent/Highly Virulent: Causing severe symptoms in a susceptible individual (ie the more virulent the organism, the more severe the symptoms).
       
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