The Scottish Government

Recently Completed Scottish Research Studies

Study
description

Location

Date

Age Group/
Gender/
Status

Scottish sample (number of respondents)

Methodology

References

Pilot case-control study of polymorphisms in MTHFR and colorectal cancer

Grampian

Recruitment Completed 1997

Males and females 37-77yrs.

Cases were recently diagnosed invasive colorectal cancer and controls were selected from general practice lists in Grampian area.
79 cases and 79 controls.

SCG-MRC/FFQ
Plus mouthwash DNA analysed for polymorphisms in MTHFR gene.

Howe et al, 1997
Contact
Prof Julian Little and Linda Sharp

Interactions between diet and polymorphic genes involved in nutrient metabolism in the aetiology of cleft lip and palate
Case-control study

Scotland,
Northern Ireland,
England

1997-2000

Parents and children.

Children born with cleft lip/palate between 1997 and 2000 and their parents.
Control children and parents selected from CHI (Scotland), Health Board Register (N. Ireland) and GP practices (England).
Total number of cases 221, controls 251.

SCG-MRC/FFQ
Plus mouthwash DNA analysed for polymorphisms in MTHFR (and other genes). Blood samples analysed for folate biomarkers.

Contact
Prof Julian Little

The effect of folic acid supplementation on plasma homocysteine in an elderly population
Randomised double blind placebo control trial

Aberdeen

1997-2000

65-75
Males and females.

Sample drawn from GP practices in Aberdeen.
368 Subjects.

Dietary folate intake assessed at baseline and after 6 weeks of supplementation using the Scottish Heart Health / MONICA FFQ.
Analysis carried out at the Rowett Research Institute.

Rydlewicz et al., 2001